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Meftal Spas dosage: how to take it

Also in: हिन्दी தமிழ் मराठी తెలుగు ಕನ್ನಡ বাংলা ગુજરાતી മലയാളം

Also known as: Meftal Spas, Meftal-Spas, Meftal Spas tablet

Take Meftal Spas exactly as your doctor advises or as printed on the pack. Do not take more, more often, or for longer than directed.

Meftal Spas: Uses, How It Works, Side Effects

Active ingredient
Mefenamic acid 250 mg + Dicyclomine 10 mg
Type of medicine
Non-steroidal anti-inflammatory drugs (NSAIDs), Antispasmodics
Used for
Abdominal cramps, Period pain
Starts working in
Usually within about 1 to 2 hours
Effect lasts
About 6 to 8 hours
With or without food
Take with or just after food
Alcohol
Avoid
Pregnancy
Not usually recommended. Ask your doctor
Habit-forming
No
Made by
Blue Cross Laboratories

Pharmacist review in progress. This page is based on the sources listed below and is being checked by our registered pharmacist.

On this page
  1. How to take Meftal Spas
  2. Who should be careful
  3. Medicines and things that interact with Meftal Spas
  4. If someone takes too much
  5. Common questions

How to take Meftal Spas

Take Meftal Spas exactly as your doctor advises or as printed on the pack. Do not take more, more often, or for longer than directed.

  • Take it with or just after food, with a glass of water, to lower the chance of stomach upset.
  • It is meant for short courses. For period pain it is usually taken only on the days the pain is present, starting when the pain or bleeding begins.
  • Use the lowest dose that works for the shortest time. Do not take it regularly for weeks without a doctor's review.
  • Do not take it together with other NSAID painkillers such as ibuprofen, diclofenac, aceclofenac, naproxen or aspirin, or with another medicine that contains mefenamic acid or dicyclomine. Check the labels of combination products.
  • Stop taking it and talk to a doctor if you get diarrhoea or a skin rash.
  • Meftal Spas tablets are not meant for children. Products for children have a different formula and should be given only on a doctor's advice.
  • See a doctor if period pain is severe, getting worse or not relieved, or if tummy pain is sudden, severe, or comes with fever, vomiting or blood in the stools.

Who should be careful

Meftal Spas is not suitable for everyone. Check with a doctor before taking it if any of the following apply to you.

  • A stomach ulcer or stomach bleeding now or in the past, or inflammatory bowel disease (Crohn's disease or ulcerative colitis)
  • Asthma, especially if aspirin or other painkillers have made your breathing worse, or a past allergy to any NSAID
  • Kidney, liver or heart disease, high blood pressure, a past heart attack or stroke, or recent heart bypass surgery
  • Glaucoma (raised pressure in the eye), an enlarged prostate or difficulty passing urine: dicyclomine can make these worse, and the medicine is generally not suitable
  • Myasthenia gravis, a blockage in the gut, or reflux with inflammation of the food pipe
  • Age over 65: a higher chance of stomach bleeding, kidney problems and confusion
  • Pregnancy: NSAIDs such as mefenamic acid are generally avoided from about 20 weeks of pregnancy and must not be used in the last 3 months. Earlier in pregnancy, use it only if a doctor advises it
  • Breastfeeding: not usually recommended, because dicyclomine passes into breast milk and young babies are sensitive to it
  • Hot weather or hard physical work: dicyclomine reduces sweating, which raises the risk of overheating and heat stroke
  • Driving or using machines: it can cause drowsiness, dizziness or blurred vision
  • Children: Meftal Spas tablets are not meant for children

Medicines and things that interact with Meftal Spas

Meftal Spas can interact with several medicines. Tell your doctor or pharmacist about everything you take, including painkillers bought without a prescription.

  • Other NSAIDs, including ibuprofen (also in Combiflam), diclofenac, aceclofenac, naproxen and aspirin: higher risk of stomach ulcers and bleeding
  • Blood thinners such as warfarin, and antiplatelet medicines such as clopidogrel or low-dose aspirin: higher risk of bleeding
  • Antidepressants such as fluoxetine, sertraline, escitalopram (SSRIs) or venlafaxine (SNRIs): higher risk of stomach bleeding
  • Steroid tablets such as prednisolone: higher risk of stomach ulcers and bleeding
  • Lithium and methotrexate: their levels in the blood can rise to harmful levels
  • Blood pressure medicines such as ACE inhibitors (for example ramipril), ARBs (for example telmisartan) and diuretics (water tablets): they may work less well, and the kidneys can be harmed, especially if you are dehydrated
  • Digoxin (a heart medicine): its level in the blood can rise
  • Other medicines with anticholinergic effects, such as some antihistamines, tricyclic antidepressants (for example amitriptyline) and antipsychotics: more dry mouth, constipation, blurred vision, drowsiness and confusion
  • Metoclopramide and domperidone (for nausea): dicyclomine works against their effect on the gut
  • Antacids: those containing magnesium hydroxide can increase the absorption of mefenamic acid, and antacids can reduce the absorption of dicyclomine. Ask a pharmacist how to space the doses
  • Quinolone antibiotics such as ciprofloxacin: NSAIDs may increase the risk of fits
  • Alcohol: increases the risk of stomach bleeding and makes drowsiness worse

If someone takes too much

Taking too much Meftal Spas is a medical emergency. An overdose of mefenamic acid can cause fits (seizures), drowsiness, vomiting, stomach bleeding, and kidney or liver damage. Too much dicyclomine can cause hot, dry skin, wide pupils, a fast heartbeat, confusion and muscle weakness. Call 112 or go to the nearest hospital immediately and take the medicine pack with you.

Common questions

Can I take Meftal Spas on an empty stomach?

It is better not to. Mefenamic acid can irritate the stomach lining, so take Meftal Spas with or just after food, with water. Stop and see a doctor if you get severe stomach pain, black stools or vomit with blood.

How long does Meftal Spas take to work?

Relief usually starts within about 1 to 2 hours. Dicyclomine is absorbed within about an hour, and mefenamic acid reaches its highest level in the blood in about 2 to 4 hours. Do not take the next dose sooner than your doctor or the label advises.

Can I drink alcohol while taking Meftal Spas?

It is best to avoid alcohol. Alcohol adds to the stomach irritation and bleeding risk of mefenamic acid, and it can make the drowsiness and dizziness caused by dicyclomine worse.

Can I take Meftal Spas with Combiflam, ibuprofen or Dolo 650?

Do not take it with Combiflam, ibuprofen, diclofenac or other NSAIDs, because two NSAIDs together raise the risk of stomach bleeding and kidney problems. Paracetamol, as in Dolo 650, is not an NSAID, but ask your doctor or pharmacist before combining any painkillers.

Sources

  1. Monthly Drug Safety Alert, November 2023 (File No. P.17019/01/2023-DA, dated 30 November 2023). Indian Pharmacopoeia Commission, Pharmacovigilance Programme of India (PvPI)
  2. Drug Alerts 2023. Indian Pharmacopoeia Commission
  3. ADR Reporting. Indian Pharmacopoeia Commission, Pharmacovigilance Programme of India (PvPI)
  4. IPC alert advises patients to monitor possibility of mefenamic acid's adverse effects: Meftal makers. The Tribune (news report, December 2023)
  5. List of drugs prohibited for manufacture and sale through gazette notifications under section 26A of the Drugs & Cosmetics Act 1940. Central Drugs Standard Control Organisation (CDSCO)
  6. List of prohibited FDC drugs (156 FDCs) dated 02.08.2024. Central Drugs Standard Control Organisation (CDSCO)
  7. PONSTEL (mefenamic acid capsules) prescribing information and Medication Guide (revised 12/2025). US Food and Drug Administration
  8. Mefenamic acid capsule label. DailyMed, US National Library of Medicine
  9. Ponstan Capsules 250mg: Summary of Product Characteristics. electronic medicines compendium (emc), UK
  10. BENTYL (dicyclomine hydrochloride) prescribing information. US Food and Drug Administration
  11. Dicyclomine hydrochloride tablet label. DailyMed, US National Library of Medicine
  12. Dicycloverine 10 mg Tablets: Summary of Product Characteristics. electronic medicines compendium (emc), UK
  13. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). StatPearls, National Center for Biotechnology Information (NCBI), US National Library of Medicine
  14. Dysmenorrhea. StatPearls, National Center for Biotechnology Information (NCBI), US National Library of Medicine
  15. Mefenamic Acid (Drugs and Lactation Database, LactMed). National Center for Biotechnology Information (NCBI), US National Library of Medicine
  16. Dicyclomine (Drugs and Lactation Database, LactMed). National Center for Biotechnology Information (NCBI), US National Library of Medicine
  17. FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later because they can result in low amniotic fluid (Drug Safety Communication, October 2020). US Food and Drug Administration
  18. NSAIDs. NHS (UK)
  19. Period pain. NHS (UK)