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Augmentin 625 Duo side effects: common and serious

Also in: हिन्दी தமிழ் मराठी తెలుగు ಕನ್ನಡ বাংলা ગુજરાતી മലയാളം

Also known as: Augmentin 625, Augmentin Duo, Augmentin 625 tablet

Most people take Augmentin 625 Duo without serious problems, but side effects in the stomach and gut are common, and diarrhoea is the most frequent. You can report side effects to the Pharmacovigilance Programme of India helpline, 1800-180-3024.

Augmentin 625 Duo: Uses, How It Works, Side Effects

Active ingredient
Amoxicillin 500 mg + Clavulanic acid 125 mg
Type of medicine
Penicillins, Beta-lactamase inhibitors
Used for
Bacterial skin infections, Respiratory tract infections, Urinary tract infections (UTIs)
Starts working in
Most people start to feel better within a few days
Effect lasts
Each dose covers about 8 to 12 hours
With or without food
Take at the start of a meal
Alcohol
No known interaction. Ask your doctor
Pregnancy
Only if a doctor says it is needed
Habit-forming
No
Made by
GlaxoSmithKline Pharmaceuticals Ltd

Pharmacist review in progress. This page is based on the sources listed below and is being checked by our registered pharmacist.

On this page
  1. Side effects of Augmentin 625 Duo
  2. Who should be careful
  3. If someone takes too much
  4. Common questions

Side effects of Augmentin 625 Duo

Most people take Augmentin 625 Duo without serious problems, but side effects in the stomach and gut are common, and diarrhoea is the most frequent. You can report side effects to the Pharmacovigilance Programme of India helpline, 1800-180-3024.

Uncommon or mild

  • Diarrhoea or loose stools
  • Nausea or vomiting (less likely if it is taken at the start of a meal)
  • Thrush: white patches in the mouth, or itching and discharge from the vagina
  • Indigestion or stomach discomfort
  • Mild skin rash or itching
  • Headache or dizziness

Rare but serious: get medical help

  • Signs of a severe allergic reaction: swelling of the face, lips, tongue or throat, wheezing, difficulty breathing or fainting. Get emergency help immediately
  • A widespread rash with blisters, peeling skin, or sores in the mouth or eyes, or a rash with fever and swollen glands
  • Severe or watery diarrhoea that does not stop, or diarrhoea with blood or mucus and stomach cramps, during the course or up to two months after it
  • Yellow skin or eyes, dark urine, pale stools or pain in the upper right side of the tummy. Liver problems can appear up to several weeks after the course ends
  • Repeated vomiting a few hours after each dose, with paleness or drowsiness, especially in children
  • Chest pain together with signs of an allergic reaction
  • Unusual bruising or bleeding, or fever with a rash, swollen glands and feeling very unwell, which can be signs of a rare blood or immune problem
  • Passing very little urine, blood in the urine, or fits (seizures)

Who should be careful

Augmentin 625 Duo is not suitable for everyone. Tell your doctor before taking it if any of the following apply to you.

  • Allergy to penicillin, amoxicillin, cephalosporins or any other antibiotic: it must not be taken by people who have had an allergic reaction to penicillins or cephalosporins
  • Jaundice or liver problems in the past after taking amoxicillin with clavulanic acid: it must not be taken again
  • Liver disease: the doctor may check your liver function during treatment
  • Kidney disease: a lower dose or fewer doses a day may be needed
  • Glandular fever (infectious mononucleosis): amoxicillin very often causes a rash in people with this viral infection, so it should be avoided
  • Pregnancy: it is used in pregnancy only when a doctor judges it necessary. One study linked its use in women whose waters broke early, before labour, with a serious bowel problem in newborns
  • Breastfeeding: small amounts pass into breast milk. Watch the baby for diarrhoea, thrush, rash or poor feeding, and tell your doctor
  • Long courses: other germs such as yeasts can overgrow, and the doctor may check your blood, liver and kidney function
  • Colds, flu and most coughs and sore throats are caused by viruses: this antibiotic does not help them

If someone takes too much

Taking more Augmentin 625 Duo than prescribed can cause stomach pain, vomiting and diarrhoea, with loss of body fluids. Rarely, very large doses can cause fits or crystals in the urine that harm the kidneys. If someone has taken too much, call 112 or go to the nearest hospital immediately and take the medicine pack with you.

Common questions

Why does Augmentin 625 Duo cause diarrhoea?

The antibiotic also kills some of the helpful bacteria in the gut. Mild diarrhoea is common, so drink plenty of fluids. Contact a doctor quickly if diarrhoea is severe or watery, has blood or mucus, or comes with cramps or fever, even weeks after the course.

Can I take Augmentin 625 Duo if I am allergic to penicillin?

No. It contains amoxicillin, a penicillin, and must not be taken by people who have had an allergic reaction to penicillins or cephalosporins. Tell every doctor and pharmacist about any antibiotic allergy.

Can Augmentin 625 Duo affect the liver?

Rarely. It can cause hepatitis or jaundice, more often in older people, men and those on long courses, and signs can appear up to several weeks after the course ends. Get medical advice for yellow skin or eyes, dark urine, pale stools or tummy pain. People who had jaundice with it before must not take it again.

Sources

  1. AUGMENTIN 625 / 1g DUO (amoxycillin and potassium clavulanate tablets IP): prescribing information (revised 16 October 2025). GlaxoSmithKline Pharmaceuticals Limited, India
  2. AUGMENTIN (amoxicillin and clavulanate potassium) tablets, chewable tablets and oral suspension: full prescribing information (revised 7/2026). US Food and Drug Administration
  3. Augmentin 625mg Tablets: Summary of Product Characteristics. electronic medicines compendium (emc), UK
  4. Co-amoxiclav: antibiotic to treat bacterial infections. NHS (UK)
  5. Antibiotics. NHS (UK)
  6. Amoxicillin Clavulanate. StatPearls, National Center for Biotechnology Information (NCBI), US National Library of Medicine
  7. Amoxicillin-Clavulanate (LiverTox: Clinical and Research Information on Drug-Induced Liver Injury). National Institute of Diabetes and Digestive and Kidney Diseases, via NCBI Bookshelf
  8. Amoxicillin and Clavulanic Acid (Drugs and Lactation Database, LactMed). National Center for Biotechnology Information (NCBI), US National Library of Medicine
  9. List of drugs prohibited for manufacture and sale through gazette notifications under section 26A of the Drugs & Cosmetics Act 1940. Central Drugs Standard Control Organisation (CDSCO)
  10. List of prohibited FDC drugs (156 FDCs) dated 02.08.2024. Central Drugs Standard Control Organisation (CDSCO)
  11. ADR Reporting. Indian Pharmacopoeia Commission, Pharmacovigilance Programme of India (PvPI)