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Augmentin 625 Duo dosage: how to take it

Also in: हिन्दी தமிழ் मराठी తెలుగు ಕನ್ನಡ বাংলা ગુજરાતી മലയാളം

Also known as: Augmentin 625, Augmentin Duo, Augmentin 625 tablet

Take Augmentin 625 Duo exactly as your doctor prescribes or as printed on the pack. The number of doses a day and the length of the course depend on the infection, your kidney function and your doctor's advice.

Augmentin 625 Duo: Uses, How It Works, Side Effects

Active ingredient
Amoxicillin 500 mg + Clavulanic acid 125 mg
Type of medicine
Penicillins, Beta-lactamase inhibitors
Used for
Bacterial skin infections, Respiratory tract infections, Urinary tract infections (UTIs)
Starts working in
Most people start to feel better within a few days
Effect lasts
Each dose covers about 8 to 12 hours
With or without food
Take at the start of a meal
Alcohol
No known interaction. Ask your doctor
Pregnancy
Only if a doctor says it is needed
Habit-forming
No
Made by
GlaxoSmithKline Pharmaceuticals Ltd

Pharmacist review in progress. This page is based on the sources listed below and is being checked by our registered pharmacist.

On this page
  1. How to take Augmentin 625 Duo
  2. Who should be careful
  3. Medicines and things that interact with Augmentin 625 Duo
  4. If someone takes too much
  5. Common questions

How to take Augmentin 625 Duo

Take Augmentin 625 Duo exactly as your doctor prescribes or as printed on the pack. The number of doses a day and the length of the course depend on the infection, your kidney function and your doctor's advice.

  • It is usually taken twice a day, about 12 hours apart, and sometimes three times a day for more severe infections, as the doctor prescribes.
  • Take it at the start of a meal, with a glass of water. Swallow the tablet whole; do not break or chew it.
  • Complete the course your doctor prescribes, even if you feel better sooner. Stopping early can let the infection come back and adds to antibiotic resistance.
  • If you miss a dose, take it when you remember, unless the next dose is nearly due. Do not take two doses together.
  • The course is usually short. The label says treatment should not go beyond 14 days without a doctor's review.
  • Augmentin 625 Duo tablets are not recommended for children aged 12 and under. Other forms with different strengths are made for children and are given only on a doctor's advice.
  • Do not keep leftover tablets for later or share them with anyone else. An antibiotic should be taken only for an infection a doctor has diagnosed.

Who should be careful

Augmentin 625 Duo is not suitable for everyone. Tell your doctor before taking it if any of the following apply to you.

  • Allergy to penicillin, amoxicillin, cephalosporins or any other antibiotic: it must not be taken by people who have had an allergic reaction to penicillins or cephalosporins
  • Jaundice or liver problems in the past after taking amoxicillin with clavulanic acid: it must not be taken again
  • Liver disease: the doctor may check your liver function during treatment
  • Kidney disease: a lower dose or fewer doses a day may be needed
  • Glandular fever (infectious mononucleosis): amoxicillin very often causes a rash in people with this viral infection, so it should be avoided
  • Pregnancy: it is used in pregnancy only when a doctor judges it necessary. One study linked its use in women whose waters broke early, before labour, with a serious bowel problem in newborns
  • Breastfeeding: small amounts pass into breast milk. Watch the baby for diarrhoea, thrush, rash or poor feeding, and tell your doctor
  • Long courses: other germs such as yeasts can overgrow, and the doctor may check your blood, liver and kidney function
  • Colds, flu and most coughs and sore throats are caused by viruses: this antibiotic does not help them

Medicines and things that interact with Augmentin 625 Duo

Augmentin 625 Duo can interact with some medicines. Tell your doctor or pharmacist about everything you take, including medicines bought without a prescription.

  • Blood thinners such as warfarin or acenocoumarol: the blood can take longer to clot, so your INR may need extra checks
  • Methotrexate: penicillins can slow its removal from the body and raise the risk of side effects
  • Allopurinol (for gout): skin rashes become more likely
  • Probenecid: raises amoxicillin levels; using them together is not recommended
  • Mycophenolate mofetil (used after organ transplants): its level in the blood may fall, so the doctor may monitor you
  • Birth control pills: the Indian label says antibiotics may make the combined pill less effective, and vomiting or severe diarrhoea can also stop the pill being absorbed. Ask your doctor whether you need extra contraception
  • Urine sugar tests: some older urine glucose tests can give a false positive result

If someone takes too much

Taking more Augmentin 625 Duo than prescribed can cause stomach pain, vomiting and diarrhoea, with loss of body fluids. Rarely, very large doses can cause fits or crystals in the urine that harm the kidneys. If someone has taken too much, call 112 or go to the nearest hospital immediately and take the medicine pack with you.

Common questions

What does 625 Duo mean?

The number 625 is the total of amoxicillin 500 mg and clavulanic acid 125 mg in each tablet. Duo refers to the twice-a-day dosing used for mild to moderate infections, about one tablet every 12 hours. For more severe infections a doctor may prescribe it three times a day.

Should I take Augmentin 625 Duo before or after food?

Take it at the start of a meal. Food helps the body absorb clavulanic acid and lowers the chance of nausea and stomach upset. Swallow the tablet whole with water.

Can I stop taking Augmentin 625 Duo when I feel better?

Take it for as long as your doctor prescribes, even if you feel better after a few days. Stopping early can let the infection come back and adds to antibiotic resistance. If side effects are troubling you, talk to your doctor.

Can I drink alcohol while taking Augmentin 625 Duo?

No direct interaction between alcohol and amoxicillin with clavulanic acid is listed on the label. Alcohol can still add to stomach upset and make you feel worse while you are unwell, so ask your doctor.

Sources

  1. AUGMENTIN 625 / 1g DUO (amoxycillin and potassium clavulanate tablets IP): prescribing information (revised 16 October 2025). GlaxoSmithKline Pharmaceuticals Limited, India
  2. AUGMENTIN (amoxicillin and clavulanate potassium) tablets, chewable tablets and oral suspension: full prescribing information (revised 7/2026). US Food and Drug Administration
  3. Augmentin 625mg Tablets: Summary of Product Characteristics. electronic medicines compendium (emc), UK
  4. Co-amoxiclav: antibiotic to treat bacterial infections. NHS (UK)
  5. Antibiotics. NHS (UK)
  6. Amoxicillin Clavulanate. StatPearls, National Center for Biotechnology Information (NCBI), US National Library of Medicine
  7. Amoxicillin-Clavulanate (LiverTox: Clinical and Research Information on Drug-Induced Liver Injury). National Institute of Diabetes and Digestive and Kidney Diseases, via NCBI Bookshelf
  8. Amoxicillin and Clavulanic Acid (Drugs and Lactation Database, LactMed). National Center for Biotechnology Information (NCBI), US National Library of Medicine
  9. List of drugs prohibited for manufacture and sale through gazette notifications under section 26A of the Drugs & Cosmetics Act 1940. Central Drugs Standard Control Organisation (CDSCO)
  10. List of prohibited FDC drugs (156 FDCs) dated 02.08.2024. Central Drugs Standard Control Organisation (CDSCO)
  11. ADR Reporting. Indian Pharmacopoeia Commission, Pharmacovigilance Programme of India (PvPI)